The Vitamin D receptor (VDR) is a nuclear transcriptional regulator of multiple genes. The pleiotropic results on multiple physiological devices make it a desired target pertaining to investigating disease mechanisms and therapeutic responses. In an in-vitro assay, the FokI CC genotype of VDR showed a larger response to 1, 25-dihydroxyvitamin D3 (VitD3) in contrast to the TT genotype. The difference in response could possibly be due to the gear expression of numerous enzymes associated with hydroxylase activity and the formation of 25-dihydroxyvitamin D3 in the two genotypes.

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